From I-264 East or I-65 North

Travel on I-65 North to I-64 West (towards St. Louis) and take Third Street exit (Exit 5B). Stay in right lane of the ramp to turn right on River Road. Go two blocks and turn left on Sixth Street. Go one block to Main Street (you will pass by Muhammad Ali Center on your right). 600 West Main is on the Southwest corner of Main and Sixth.

From Frankfort or Lexington:
Take I-64 West to Third Street exit (Exit 5B). Stay in right lane of the ramp to turn right on River Road. Go two blocks and turn left on Sixth Street. Go one block to Main Street (you will pass by Muhammad Ali Center on your right). 600 West Main is on the Southwest corner of Main and Sixth.

From Jeffersonville:
Take I-65 across the Kennedy Bridge. Take I-64 West to Third Street exit (Exit 5B). Stay in right lane of the ramp to turn right on River Road. Go two blocks and turn left on Sixth Street. Go one block to Main Street (you will pass by Muhammad Ali Center on your right). 600 West Main is on the Southwest corner of Main and Sixth.

From Indianapolis:
Take I-65 across the Kennedy Bridge. Take I-64 West to Third Street exit (Exit 5B). Stay in right lane of the ramp to turn right on River Road. Go two blocks and turn left on Sixth Street. Go one block to Main Street (you will pass by Muhammad Ali Center on your right). 600 West Main is on the Southwest corner of Main and Sixth.

From Cincinnati:
Take I-71 South toward Louisville approximately 23.6 miles.
Merge onto I-71 South (Exit I-71 SOU) toward Louisville.
Travel approximately 76.3 miles to I-64 West (Exit 1A) toward St. Louis.
Take I-64 West to Third Street exit (Exit 5B).
Travel three blocks and turn left onto 6th Street.
Travel one block and turn left on Market Street.
Stay in right lane of the ramp to turn right on River Road. Go two blocks and turn left on Sixth Street. Go one block to Main Street (you will pass by Muhammad Ali Center on your right).